Patient-derived > 항암유효성평가지원센터

An effectiveness test with patient-derived primary cells, patient-derived xenograft, patient-derived xenograft, and patient samples will facilitate progression to clinical trials and the acceleration of new drug development.

List of Models

Patient-Derived primary cells (PPC)	Panels : liver cancer, ovarian cancer, colorectal cancer, gastric cancer, prostate cancer, lung cancer - B-raf, EGFR, Her2, K-ras, PI3K, Homologous Recombination Deficiency (HRD) diagnosis, Androgen receptor etc. Clinically annotated patient-derived model Patient-derived model with patient information and whole exome sequencing
Patient-derived xenografts(PDX)	Panels : colorectal cancer, liver cancer, lung cancer, pancreatic cancer, gastric cancer, renal cell carcinoma, ovarian cancer, uterine cancer, bile duct cancer, prostate cancer etc. - Lung cancer: Genome analysis (whole exome sequencing etc), radiotherapy reactive data attachment - Gastric cancer: HER2-positive & Herceptin reactive data attachment, genome analysis result attachment - Colorectal cancer: Radiotherapy reactive, Irinotecan reactive data attachment - Ovarian cancer: Olaparib reactive data attachment, genome analysis attachment - Cholangiocarcinoma: FGFR4-positive etc - Pancreas cancer: Gemcitabine reactive data attachment - Liver cancer: Sorafenib reactive data attachment - Kidney cancer: Sunitinib reactive data attachment
Patient-derived organoid (PDO)	Panels : colorectal cancer, liver cancer, lung cancer, gastric cancer and normal colon, liver, lung, stomach Clinically annotated patient-derived models - Models with data such as K-ras, EGFR, Her2 mutations, homologous recombination deficiency (HRD) diagnosis base, etc. Patient-derived model with patient information, whole exome sequencing, and RNA sequencing - Model with data such as PDL-1 expression and gene expression pattern analysis
Patient specimens	Cryopreserved cancer tissue, normal tissue and blood with clinical information Paraffin embedded cancer and normal tissue

Service

Customized model selection and test design
Biomarker verification
MOA & POC verification
Verification of drug efficacy based on genetic characteristics.
In vitro drug efficacy test
Cell viability/ Death assay/ Synergy index
Signal pathway assay: Immunocytochemistry, Immuno blotting, Immunoprecipitation, ELISA, Q-PCR
PDX can be produced using organoids on demand
(verification of simultaneous drug efficacy ofIn vitro / In vivo models)
Tumor growth inhibition/delay test
Kaplan-Meier survival test
Radiotherapy response test
Histological analysis
Tissue preparation, IHC, TUNEL, DNA/RNA/protein extraction etc

Service example

Utilizing patient-derived models tailored to drug characteristics

Evaluation of tumor growth inhibition efficacy by drug treatment