List of Models
|
Model |
Cancer type |
Cell line |
|
Subcutaneous Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Colon |
CT26.WT (BALB/c), MC-38 (C57BL/6) |
|
|
Fibrosarcoma |
FSa-II (BALB/c) |
|
|
Lung |
LLC1 (C57BL/6) |
|
|
Melanoma |
B16/F10 (C57BL/6) |
|
|
Ovary |
ID8 (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Orthotopic Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Ovary |
ID8-Luc (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Metastasis Syngeneic Model |
Breast |
4T1-Luc-TdTomato (Mammary Fat Pad Injection) 4T1-Luc-TdTomato (Intracardiac Injection) 4T1-Luc-TdTomato (Intravenous Injection) |
|
Leukemia |
WEHI-3 (Mouse Leukemia) |
|
|
Spontaneous Model (GEM) |
Lung |
Induced by p53/ras mutation |
|
Humanized Mouse (hHSC) |
Breast |
MDA-MB-231-Luc |
|
Colon |
HT29 |
|
|
Liver |
Hep3B-Luc, Huh-7-Luc, HepG2.2.15 |
|
|
Pancreas |
AsPC-1-Luc, BXPC-3-Luc, QGP1 |
|
|
Endometrial |
Hec-1A, Ishikawa |
|
|
Ovary |
ES-2-Luc, SKOV-3-Luc |
Service
- Customized study design (in vitro, in vivo, ex vivo)
- Tumor growth inhibition/delay studies using mouse models
- Evaluation of monotherapy and combination therapy with immune-oncology drugs (e.g., anti-PD-(L)1, anti-CTLA4)
- Immune cell immunophenotyping Histological analysis within the tumor microenvironment using FACS (Tissue preparation, IHC, TUNEL)
- In vivo imaging
- Live animal IVIS imaging, MRI, PET, PET-MR, CT
- ADCC (Antibody-dependent cell mediated cytotoxicity), CDC (Complement dependent cytotoxicity) assay
- Treg (Regulatory T cell) suppression assay
- Metastasis inhibition assay
- Immuno-radiotherapy response assay
- Mouse tumor-infiltrated lymphocyte (TIL) analysis
- Human T cell analysis: MLR assay / CEFT assay / CMV Antigen Recall Assay
- PD-1:PD-L1 Inhibitor Screening Assay
Service example
Analysis of tumor-infiltrating lymphocytes within MC38 tumor