PK study using assay system and animal model for In vitro ADME profiling
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Mouse / Rat |
Analysis of drug concentrations in the blood or tissue after animal modeling |
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Rabbit / Dog |
Analysis of requested samples such as plasma and PK parameter calculation |
Service
- Bioanalysis
- Development of quantitative analysis method using pre-treatment of samples and LC-MS/MS
- Development of pre-treatment and quantitative Analysis Method Using LC-MS/MS
- In vitro ADME assay
- Parallel artificial membrane permeability assay (PAMPA)
- Caco-2 permeability assay
- Protein binding assay
- Microsomal stability
- Plasma stability
- CYP inhibition study
- In vitro metabolite identification (Met ID)
- In vivo PK study
- Rodent (mouse/rat) full PK study
- Sample analysis and PK parameter calculation when providing PK samples (e.g., plasma) of medium and large animals
- Tissue distribution experiment
- N-in-one PK study
In vivo PK study
대사안정성 시험 (Microsomal stability)
Service example (New Zealand white rabbit)
- New Zealand white rabbit stable PK test
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Test content |
- Blood was collected from the ear vein of a New Zealand white rabbit at a designated time point after a single administration of the developed material. - Collected blood is collected in a sodium heparin tube and centrifuged at 4℃, 3000rpm for 10 minutes to separate plasma. - Presents the pharmacokinetic characteristics of the developed drug for the test subject from the blood-drug concentration curve over time calculated through analysis |
|
Result |
[Blood collection time point] 
[Analysis] |
Service example (SD rat)
- SD rat 경구 투여 PK 시험
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Test content |
- Blood was collected at a volume of 0.5 mL through the caudal vein of male and female SD rats at each time point. - Collected blood is collected in a sodium heparin tube and centrifuged at 4℃, 3,000rpm for 10 minutes to separate plasma. - Presents the pharmacokinetic characteristics of the developed drug for the test subject from the blood-drug concentration curve over time calculated through analysis |
|
Result |
[Blood collection time point] 
[Analysis] |